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A 2-year 100% scientist position with possibility of elongation for a highly motivated and skilled researcher is available at the Department of Pediatric Research, OUS Rikshospitalet (https://ous-research.no/pediatricresearch/) on a project funded by the Norwegian Cancer Society.   Liquid biopsies leverage circulating molecular structures from body fluids, facilitating a less invasive yet more comprehensive diagnostic approach. Especially for childhood cancer patients it is crucial to obtain temporal and spatial insights that capture the tumor's heterogeneity and evolving structure over time. Peripheral blood is the common source for liquid biopsies; however, in childhood cancer patients, the sample volume is often restricted. In contrast, urine-derived samples are both abundant and harmless. Furthermore, recent technological advances allow for genomic, transcriptomic, proteomic, metabolomic, and methylation profiling using urine. Circulating cell-free DNA (cfDNA), extracellular vesicles (EVs), and circular RNAs (circRNAs) are linked to the onset and progression of cancer, although there remains a knowledge gap for pediatric cancers. We will employ state-of-the-art analytical methods to gain deeper insights into the frequency and composition of cfDNA, the cargo and targets of EVs, and the expression and characteristics of circRNAs. Investigating urine-derived liquid biopsies will enhance our understanding of pediatric cancer biology, thereby contributing to improved diagnostic, monitoring, and therapeutic strategies for these vulnerable patients.   The position is based on cooperation between Dr. Lars O. Baumbusch (Senior scientist and project group leader at PFI, OUS Rikshospitalet and Prof. II at Østfold University of Applied Sciences) and other local, national- and international research environments.  Oslo University Hospital is a workplace with great diversity. We believe this is crucial for solving our tasks in the best possible way. We want this diversity to be reflected among the applicants for our positions, and we encourage all qualified candidates, regardless of background, to apply! Arbeidsoppgaver   Working tasks: The candidate will conduct scientific research within the field of liquid biopsy in pediatric cancer and participate in developing the project Perform laboratory work, including exploring the frequency and composition of cfDNA, discovering the cargo and targets of EVs, and investigating the distribution and characteristics of circulating circRNA in childhood cancer Analyze and interpret genomic, transcriptomic, and proteomic data Present research findings at national and international conferences Contribute to scientific publications in peer-reviewed journals Be part of writing new applications in the field of childhood cancer research Participate in research group meetings and collaborative activities Kvalifikasjoner For å trives med arbeidsoppgaver hos oss, ser vi etter deg som har følgende kvalifikasjoner: Applicants must have: Applicants must hold a master’s degree and a PhD in biology, molecular biology, biomedicine, or biotechnology A solid practical background in cancer, genomics, transcriptomics, and proteomics research with documented results Excellent practical experience with various molecular biology techniques - hands on bench - including sequencing, qRT-PCR/ddPCR, and Western blotting Broad working experience in extraction, quantification, and analysis of small amounts of DNA, like cfDNA Experience in isolation, characterization and quantification of EVs Extensive working experience with detection, isolation, and analysis of ncRNAs Comprehensive experience with Oxford Nanopore Sequencing, including optimalization and methylation analysis Knowledge and working experience with bioinformatic analysis using Oxford Nanopore Sequencing Strong familiarity with statistical and computational approaches, including hi