Job Opportunities API

San Diego, CA or remote Erasca is a clinical-stage precision oncology company focused on discovering, developing and commercializing medicines for the benefit of patients with cancer. Our programs take novel approaches to shutting down one of cancer’s most commonly mutated signaling cascades, the RAS/MAPK pathway, which affects approximately 5.5 million lives each year worldwide. The name “Erasca” has an important embedded meaning: it is a contraction of our audacious hope to “erase cancer” that drives our mission and everything that we do on behalf of patients with cancer. Position Summary: Reporting to the Chief Medical Officer, the Senior or Executive Director, Clinical Development will drive the clinical aspects of late-stage clinical development studies or programs. This person will work closely with cross-functional teams in the management and execution of the Clinical Development Plan (CDP), in developing innovative and efficient solutions to medical and scientific clinical trial issues, and in ensuring the successful execution and completion of clinical trials. T he Senior or Executive Director, Clinical Science will also have individual study level responsibility for one or more trials . Essential Duties and Responsibilities: • Lead in the planning and execution of clinical studies to successfully move the program through pivotal trials and eventual submission, regulatory approval, and launch . • Key clinical deliverables include document development (INDs, Protocols, IBs, applicable regulatory documents, etc.), medical and scientific input into the development of deliverables required for study activation and study conduct (CRFs, SAP, data listings, etc.), data review, and other deliverables as needed. • May a ttend and contribute at meetings with Health Authorities (HAs) related to program; develop responses to HAs and IRBs on clinical/medical questions. • Represent Erasca externally at scientific meetings and congresses. • Establish and maintain strong relationships with internal teams, clinical investigators, regulatory agencies, and key stakeholders. • Gather, analyze and interpret clinical data, providing strategic insights to inform critical decisions and guide program development. • Manage clinical development timelines effectively, ensuring efficient resource allocation and achievement of milestones. • Perform all duties in keeping with the Company’s core values, policies, and all applicable regulations. Required Education and Experience: • Undergraduate degree required ; PhD, PharmD, or other relevant advanced degree in a health science field highly preferred. • At least 10 years of biotech or pharmaceutical industry experience as a clinical scientist or in a closely related clinical development function. • E xtensive experience i n oncology clinical trials required ; late-stage development experience required , early development experien ce a plus . • Experience leading clinical development contributions to regulatory submissions (e. g. ( NDA, PIP/PSP, label negotiation, Breakthrough Therapy Designation, Accelerated Review) highly preferred . • E xperience in dynamic start up or small company environment s required . • Demonstrated ability to contribute to strategic clinical planning and work effectively independently and on cross-functional teams. • Demonstrated ability to evaluate, interpret, and present complex scientific data. • Deep knowledge of biostatistics, GCP, and regulatory requirements for clinical studies ; extensive e xperience with data analysis and interpretation ; understanding of safety and pharmacovigilance principles. • Excellent verbal and written communication and presentation skills. • Demonstrated ability to achieve high performance goals and meet deadlines in a fast-paced environment; a collaborative team player with a can-do attitude and the ability to identify and implement creative solutions to complex problems. • Flexibility, with the willingness and ability to manage through strategic shifts. • Strong learning orientation, curiosity, and commitment to science and patients. The anticipated salary range for this position is $265,000 to $310,000 . The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc etera. In addition to base salary, the h ired applicant will be eligible to receive an annual bonus and an equity grant at hire and annually in the form of the option to purchase stock in the future for a specified price. Along with our casual, collaborative , and fun work and the chance to make your mark in our mission to erase cancer, Erasca offers a comprehensive and competitive benefits package that includes: Paid Time Off , Holiday , and Sick Leave , Medical, Dental and Vision Plans , Short- and Long-Term Disability , Basic and Voluntary Life/AD&D Coverage , Flexible Spending Account s (FSA , HSA, and Commute ) , Critical Illness and Accident Coverage , Pet Insurance, Employee Assistance Program , 401(k) Plan with Erasca contribution , and the opportunity to participate in an E mployee S tock P urchase P rogram. Erasca, Inc., is an Equal Opportunity Employer and takes pride in maintaining a diverse and inclusive environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of sex , race, religion, national origin, ancestry, physical or mental disability, protected medical condition, genetic information, marital status, registered domestic partner status, age, sexual orientation, military and veteran status or any other basis protected by federal, state or local law or ordinance or regulation. Contact Us ERASCA, INC. 3115 Merryfield Row Suite 300 San Diego, CA 92121 © 2026 Erasca ® , Inc. All rights reserved. Jonathan E. Lim, M.D. Chairman, CEO and Co-founder Jonathan is Chairman and CEO of Erasca, which he co-founded in July 2018 with a mission to erase cancer. He is a physician-turned-venturepreneur at City Hill and ARCH Venture who founds, funds and leads mission-driven for-profit and non-profit ventures. He has served as Chairman and/or CEO and founding investor of six biotechnology companies that have collectively achieved global regulatory approval and launch of seven therapeutic products in oncology, immunology and drug delivery, benefitting thousands of patients worldwide, while generating approximately $10 billion of shareholder value. Jonathan has pioneered transformative advancements in drug delivery and precision oncology. In drug delivery, he designed and executed landmark deals for Halozyme’s ENHANZE ® drug delivery technology with Roche/Genentech and Baxter that formed the foundational business model and template for the company’s ten global alliances and five approved ENHANZE products that have enabled Halozyme to turn EBITDA positive and guide to $1 billion in royalty revenue in 2027. In precision oncology, Jonathan led Ignyta’s trailblazing pursuit of a global tissue agnostic label to transform cancer treatment with ROZLYTREK ® (entrectinib) that, in the process of securing global regulatory approvals, became the first drug in biopharmaceutical history to achieve the unprecedented triple crown of breakthrough designations with BTD (FDA), PRIME (EMA) and Sakigake (PMDA). He led the strategic process that successfully resulted in the acquisition of Ignyta to become a key personalized healthcare pillar for Roche/Genentech, the leading precision oncology company in the world. He is continuing to pursue new frontiers of precision oncology at Erasca. YOU ARE NOW LEAVING THE ERASCA WEBSITE Erasca is not responsible for the content of linked third party websites. Please be aware that the privacy policies and terms of use on these sites are different from Erasca’s policies.