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San Diego, CA or remote Erasca is a clinical-stage precision oncology company focused on discovering, developing and commercializing medicines for the benefit of patients with cancer. Our programs take novel approaches to shutting down one of cancer’s most commonly mutated signaling cascades, the RAS/MAPK pathway, which affects approximately 5.5 million lives each year worldwide. The name “Erasca” has an important embedded meaning: it is a contraction of our audacious hope to “erase cancer” that drives our mission and everything that we do on behalf of patients with cancer. Reporting to the Chief Medical Officer, the SVP Biometrics will be accountable for biometrics activities for all programs from IND-enabling to registration and launch. This includes leadership of the Biostatistics, Statistical Programming & Analysis, and Clinical Data Management functions. This role requires hands-on execution as well as oversight of internal and external staff. In addition, this person will represent the Biometrics function on the Erasca leadership team and in cross-functional discussions and decision making. The ideal candidate will have excellent technical skills, a track record of developing and mentoring strong teams, significant experience in all phases of oncology drug development, a track record of successful regulatory interactions, and excellent communication skills and executive presence. Essential D uties and R e sponsibilities : • Build, m aintain , and develop a high performing team across Biostatistics, Statistical Programming & Analysis , and Clinical Data Management. • Ensure systems, capabilities and resources are in place that optimize the design, conduct, analysis and interpretation of clinical and nonclinical data for all program s . • Demonstrate technical excellence , delivering advanced biometric strategies across the portfolio. • Act as the subject matter expert for biometrics, advising senior management, development, and clinical operations teams on current biostatistics methodology and tools in drug development. • In collaboration with VP , Biostatistics, ensure statistical analysis and submission datasets meet regulatory requirements. • In collaboration with VP, Statistical Programming & Analysis, ensure the intended analyses are performed, and analysis data sets and their specifications are in place. • In collaboration with Sr Director, Clinical Data Management, provide support to clinical study teams on the collection, interpretation and reporting of clinical data. • Provide input on key development documents, clinical protocols, study reports, IBs, INDs, NDAs, and labeling for all products. • Support preparations for interactions with regulatory agencies and provide guidance to ensure high quality preparation of Regulatory Authority documents (clinical study reports, submissions, clinical protocols, safety reports, etc.). Represent biometrics in interactions with regulatory agencies and health authorities. • Review and comment on eCRFs, annotated eCRFs, edit checks documents, and other clinical data management related documents. • Stay abreast of emerging technologies and concepts related to applied statistical methodology . • Lead biometrics due diligence in support of business and corporate development activities. • Establish and further embed biometrics SOPs, processes, and relevant quality management system . • Ensure appropriate resourcing of the biometrics organization by anticipating needs and filling gaps, as needed, with consultants, contractors, and/or employees. • Mentor and promote the professional development of Biometrics team members. • Up to 25% travel may be required , possible international travel . • Perform all duties in keeping with the Company’s core values, policies and all applicable regulations. Required Education and Experience: • Minimum of 15 years relevant experience in the pharmaceutical or biotechnology industry, ideally including both large and small company experience . • PhD degree in statistics or biostatistics required . • A hands on and flexible leader, comfortable as a subject matter expert for b iometrics as well as contributing at the leadership team and leading and managing highly accomplished function managers . • Experience in oncology drug development required , ideally from FIH to registration. • Direct experience leading and working in Biostatistics required as well as experience leading Statistical Programming and/or Clinical Data Management . • Extensive knowledge of clinical research methodology and regulatory requirements as they relate to trial design and analysis. • Good knowledge of ICH, FDA, and GCP regulations and guidelines; strong well-rounded technical skill , SAS, SDTM, and CDISC. • Extensive experience negotiating successfully with health authorities. • Excellent analytical and organizational skills. • Track record of successfully working within individual protocols and across programs to design, drive, and execute statistical strategy. • Proven ability to attract, develop, and manage top notch talent including a mix of internal and contingent staff. • Highly collaborative team player who fosters open communication and facilitates mutual understanding and cooperation between all stakeholders. • Executive leadership skills to educate and influence stakeholders and to add value in strategic business planning and decision-making. • Effective interpersonal, communication, and influencing skills, including strong writing and presentation skills, with the ability to tailor communication style to diverse audiences and situations. • Demonstrated ability to achieve high performance goals and meet deadlines in a fast-paced environment. • Strong learning orientation, curiosity, and commitment to science and patients. The anticipated salary range for this position is $350,000 to $415,000 . The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc etera. In addition to base salary, the h ired applicant will be eligible to receive an annual bonus and an equity grant at hire and annually in the form of the option to purchase stock in the future for a specified price. Along with our casual, collaborative , and fun work and the chance to make your mark in our mission to erase cancer, Erasca offers a comprehensive and competitive benefits package that includes: Paid Time Off , Holiday , and Sick Leave , Medical, Dental and Vision Plans , Short- and Long-Term Disability , Basic and Voluntary Life/AD&D Coverage , Flexible Spending Account s (FSA , HSA, and Commute ) , Critical Illness and Accident Coverage , Pet Insurance, Employee Assistance Program , 401(k) Plan with Erasca contribution , and the opportunity to participate in an E mployee S tock P urchase P rogram. Erasca, Inc., is an Equal Opportunity Employer and takes pride in maintaining a diverse and inclusive environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of sex , race, religion, national origin, ancestry, physical or mental disability, protected medical condition, genetic information, marital status, registered domestic partner status, age, sexual orientation, military and veteran status or any other basis protected by federal, state or local law or ordinance or regulation. Contact Us ERASCA, INC. 3115 Merryfield Row Suite 300 San Diego, CA 92121 © 2026 Erasca ® , Inc. All rights reserved. Jonathan E. Lim, M.D. Chairman, CEO and Co-founder Jonathan is Chairman and CEO of Erasca, which he co-founded in July 2018 with a mission to erase cancer. He is a physician-turned-venturepreneur at City Hill and ARCH Venture who founds, funds and leads mission-driven for-profit and non-profit ventures. He has served as Chairman and/or CEO and founding investor of six biotechnology companies that have collectively achieved global regulatory approval and launch of seven therapeutic products in oncology, immunology and drug delivery, benefitting thousands of patients worldwide, while generating approximately $10 billion of shareholder value. Jonathan has pioneered transformative advancements in drug delivery and precision oncology. In drug delivery, he designed and executed landmark deals for Halozyme’s ENHANZE ® drug delivery technology with Roche/Genentech and Baxter that formed the foundational business model and template for the company’s ten global alliances and five approved ENHANZE products that have enabled Halozyme to turn EBITDA positive and guide to $1 billion in royalty revenue in 2027. In precision oncology, Jonathan led Ignyta’s trailblazing pursuit of a global tissue agnostic label to transform cancer treatment with ROZLYTREK ® (entrectinib) that, in the process of securing global regulatory approvals, became the first drug in biopharmaceutical history to achieve the unprecedented triple crown of breakthrough designations with BTD (FDA), PRIME (EMA) and Sakigake (PMDA). He led the strategic process that successfully resulted in the acquisition of Ignyta to become a key personalized healthcare pillar for Roche/Genentech, the leading precision oncology company in the world. He is continuing to pursue new frontiers of precision oncology at Erasca. YOU ARE NOW LEAVING THE ERASCA WEBSITE Erasca is not responsible for the content of linked third party websites. Please be aware that the privacy policies and terms of use on these sites are different from Erasca’s policies.