Job Opportunities API

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future.   4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery General Summary: Vice President, Clinical Operations is responsible for strategic operational oversight and execution of one or more complex global clinical programs across the ophthalmology and/or broader portfolio. Reporting to the Chief Clinical Operations Officer , this role ensures clinical trials are planned and executed with excellence, delivering high-quality, inspection-ready data on time and within budget. The VP provides leadership to Clinical Operations teams responsible for study execution and partners closely with cross-functional development teams, including Clinical Science, Medical, Regulatory, Data Sciences, Clinical Compliance, Quality, and Business Operations, to proactively identify and mitigate operational risks, optimize trial performance, and drive executional excellence across Phase 1–3 clinical development. The VP fosters a culture of operational excellence by building scalable systems, standardized processes, and performance metrics that enable predictable execution, informed decision-making, and continuous improvement. This leader creates an environment where decisions are driven by objective data and operational metrics rather than individual effort. Major Duties and Responsibilities:  Clinical Trial Execution & Oversight Provide operational leadership and oversight for one or more large global clinical development programs or multiple phase 1-2 clinical studies from study start-up through database lock. Ensure clinical trials are executed according to timelines, quality standards, budget, and corporate objectives. Lead Clinical Operations teams to proactively identify risks, develop mitigation plans, and resolve operational challenges. Ensure consistent execution of operational strategy across studies while maintaining inspection readiness. Drive study performance through key operational metrics and continuous improvement initiatives.   Leadership & Team Management Lead, mentor, and develop Clinical Operations leaders (Senior Directors, Directors, CTMs) responsible for study execution. Foster a culture of accountability, collaboration, operational excellence, and continuous improvement. Build organizational capability through coaching and talent development. Cross-functional Leadership Partner with Clinical Science, Regulatory, Data Sciences/Medical, Clinical Compliance, Quality, Pharmacovigilance, and Technical Operations to ensure seamless trial execution. Represent Clinical Operations on cross-functional program teams. Escalate critical operational issues and r